Volume 12.25 | July 2

2020-02-07 | MCN 12.25
Mammary Cell News by STEMCELL Technologies
Vol. 12.25 – 02 July, 2020
TOP STORY

NOTCH1 Activation Compensates BRCA1 Deficiency and Promotes Triple-Negative Breast Cancer Formation

Using the sleeping beauty transposon system in Brca1-deficient mice, researchers identified 169 putative cancer drivers, among which Notch1 was a top candidate for accelerating TNBC by promoting the epithelial-mesenchymal transition and regulating the cell cycle.
[Nature Communications]

Full ArticlePress Release

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PUBLICATIONSRanked by the impact factor of the journal

Breast Cancer Colonization by Fusobacterium nucleatum Accelerates Tumor Growth and Metastatic Progression

Investigators showed that Gal-GalNAc levels increased as human breast cancer progressed, and that occurrence of F. nucleatum gDNA in breast cancer samples correlated with high Gal-GalNAc levels.
[Nature Communications]

Full Article

Fibroblast–Tumor Cell Signaling Limits HER2 Kinase Therapy Response via Activation of MTOR and Antiapoptotic Pathways

The authors demonstrated that fibroblasts reduced lapatinib sensitivity in a subset of HER2+ breast cancer cells via paracrine signaling that could be reversed by targeting downstream survival programs such as MTOR and antiapoptotic proteins.
[Proceedings of the National Academy of Sciences of the United States of America]

Full Article

HDAC6 Plays a Non-Canonical Role in the Regulation of Anti-Tumor Immune Responses, Dissemination, and Invasiveness of Breast Cancer

Scientists report new non-canonical regulatory properties of ultra-selective histone deacetylase inhibitors over the expression and function of epithelial-mesenchymal transition pathways and the invasiveness potential of breast cancer.
[Cancer Research]

Abstract

A Pygopus 2-Histone Interaction Is Critical for Cancer Cell De-Differentiation and Progression in Malignant Breast Cancer

Investigators demonstrated that the histone binding function of Pygopus 2 was important for driving de-differentiation and malignancy of breast tumors, and loss of this binding activated various differentiation pathways which attenuated primary tumor growth and metastasis formation.
[Cancer Research]

Full Article

A Novel Mitochondrial Targeted Hybrid Peptide Modified HPMA Copolymers for Breast Cancer Metastasis Suppression

Researchers designed a mitochondrial targeted drug delivery system based on N-(2-hydroxypropyl) methacrylamide copolymers to simultaneously inhibit breast cancer progression and metastasis.
[Journal of Controlled Release]

AbstractGraphical Abstract

A Novel 4-Aminoquinazoline Derivative, DHW-208, Suppresses the Growth of Human Breast Cancer Cells by Targeting the PI3K/AKT/mTOR Pathway

The authors report for the first time that DHW-208 suppressed the growth of human breast cancer cells by inhibiting the PI3K/AKT/mTOR-signaling pathway both in vivo and in vitro.
[Cell Death & Disease]

Full Article

PRKCQ Inhibition Enhances Chemosensitivity of Triple-Negative Breast Cancer by Regulating Bim

Scientists showed that Protein kinase C theta regulated the sensitivity of TNBC cells to apoptosis triggered by standard-of-care chemotherapy by regulating levels of pro-apoptotic Bim.
[Breast Cancer Research]

Full Article

Supramolecular Magnetonanohybrids for Multimodal Targeted Therapy of Triple-Negative Breast Cancer Cells

The authors introduced a novel “all-in-one nanosoldier” made of colloidal hybrid nanostructures, which were designed for simultaneously targeting, imaging, and killing TNBC cells. The results demonstrated that this novel strategy was highly effective for targeting and killing TNBC cells in vitro, expressing high levels of folate membrane-receptors.
[Journal of Materials Chemistry B]

Full Article

Deterministic Culturing of Single Cells in 3D

Researchers presented an alternate method to culture individually selected cells in relative isolation from the rest of the population under physiologically relevant matrix conditions. Using examples of breast and colorectal cancers, scientists showed that individual cells evolved into tumors or aspects of tumors displaying different characteristics of the initial cancer type and aggressiveness.
[Scientific Reports]

Full Article

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REVIEWS

Influence of Fibroblasts on Mammary Gland Development, Breast Cancer Microenvironment Remodeling, and Cancer Cell Dissemination

The authors review the latest literature describing the structure of the mammary gland and the breast cancer microenvironment (BCM) and summarize the influence of epithelial-mesenchymal transition and autophagy in breast cancer dissemination.
[Cancers]

Full Article

INDUSTRY AND POLICY NEWS

Oncolytics Biotech® Announces Investigator Sponsored Phase II Trial Evaluating Pelareorep-anti-PD-1 Combination Treatment in Triple-Negative Breast Cancer

Oncolytics Biotech® Inc announced a new investigator-sponsored triple-negative breast cancer study to be managed by Rutgers Cancer Institute of New Jersey. The phase II trial, known as IRENE, will investigate the use of pelareorep in combination with Incyte’s anti-PD-1 checkpoint inhibitor retifanlimab in patients with unresectable locally advanced or metastatic TNBC.
[Oncolytics Biotech]

Press Release

United Kingdom Plans ‘Office for Talent’ to Smooth Entry for Top Scientists

The UK government plans to set up an “office for talent” to oversee visas and make it easier to attract top scientists after Brexit, according to an R&D road map.
[ScienceInsider]

Editorial

Hong Kong Universities Rattled by New Security Law

Academics in Hong Kong are facing new worries today after the mainland government abruptly imposed a controversial new security law that critics say could infringe on human rights and chill academic freedom.
[ScienceInsider]

Editorial

FEATURED EVENT

AACR: Advances in Breast Cancer Research

October 9 – October 12
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JOB OPPORTUNITIES

Research Technician – Colorectal and Breast Cancer

University of Virginia – Charlottesville, Virginia, United States

Research Fellow – Molecular Pharmacology

Mayo Clinic – Rochester, Minnesota, United States

Postdoctoral Fellow – Cancer Research

University of Oklahoma Health Science Center – Oklahoma City, Oklahoma, United States

Laboratory Research Technician – Breast Cancer

University of Vermont – Burlington, Vermont, United States

Assistant Scientists – Cell Cycle Regulation

Georgetown University Medical Center – Washington, District of Columbia, United States

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